Reproducibility Study of Coating Efficiency on Preventing Photolytic Degradation of Betanol® (Atenolol) Tablets

Abstract

This research work was aimed to evaluate the reproducibility of the data in a study that was previously done in order to determine whether the packaging is effective to prevent the photolytic degradation of (Betanol®). The objective of this study was to determine the effect of various lighting conditions (control, sunlight, normal room light, 25 watt & 40 watt bulb) on (Betanol®). In addition, physical tests were performed to evaluate the change of weight variation, thickness and hardness of the Betanol® tablets of same batch. Physical tests were performed according to the specification of USP and very little fluctuation in result was observed throughout the study & standard deviation. Deviations for weight variation, hardness & thickness were ±0.00135 g, ±0.47284 kg & ±0.01512 cm respectively. But when it was exposed to the above mentioned lighting conditions, the concentration of Atenolol decreased gradually. Samples which were exposed to normal light, 25 watt, 40 watt electrical bulb & direct sunlight showed 20%, 21.56%, 30.70%, 36.84% degradation respectively. So it can be said that the Betanol® containing Atenolol was light sensitive and the potency decreased after exposure to light.