Abstract:
This work was proposed to determine the flow properties of different set of pharmaceutical excipients formulations that are used in directlycompressible tablets and to search for some equations which can predict the flow property of the excipients with different ratio of diluents. Here we determine the flow property of formulation with amlodipine and propranolol and compare with excipient formulation. Compressibility index, Hausner ratio, and angle of repose were used as parameters of determining flow properties. Diluents were mixed with these prepared formulas in different specific and justified ratio. The prepared mixture in a constant weight was then examined for measuring flow property with and without APIs. The values of
Carr’s index, Hausner ratio and angle of repose were plotted against the percentage ratios of diluents. The study showed a linear relationship with different ratios of mixture and flow property measuring parameters. From the graphs the straight line equation for each set of formula were obtained regression value which can be used to predict the flow property of the formula with different ratio of diluents. Moreover the most suitable ratio of specific diluents and a specific set of other excipients were proposed that showed better flow property with amlodipine and propranolol. After doing research I found that the best result comes from set-1 is ratio 5 (85% : 15%), for set-2 is ratio 5 (70% : 30%) and for set-3 is ratio 4 (85% : 15%). And bad result comes from set-1 is ratio 1 (45% : 55%), for set-2 is ratio 1 (30% : 70%) and also for set-3 is ratio 1 (55% : 45%). These equations can be used for other APIs also to determine their flow property.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
