dc.description.abstract |
The research work was proposed to find out the impact of Acical-M (Calcium, Vitamin &
Minerals tablet), Calbo (Calcium supplement tablet), Aristocal D (Calcium & vitamin-D
Tablet), Filwel Silver (Multivitamin Silver Tablet) and Nutrum Gold (Multivitamin &
Multiminerals Tablet) on the dissolution of Ranitidine (Zantac & Neoceptine). Zantac is
parent product of Ranitidine produced by GlaxoSmithKline Bangladesh and Neoceptine is
the brand name of Ranitidine produced by Square Pharmaceutical Ltd. To determine the
physical parameters of Ranitidine tablet, some important tests such as weight variation test,
hardness test and thickness test were performed. The dissolution test was performed by
using distilled water (used as dissolution medium) with USP dissolution apparatus II
followed by UV Spectroscopy. The dissolution of individual Ranitidine tablets and also
with the combination of following supplements, were determined after 20, 40 and 60
minutes. After 60 minute, the percent dissolved amount of individual Zantac and Zantac
with Calbo, Acical-M, Filwel Silver , Aristocal D and Nutrum Gold were 94.09%, 47.84%,
48.47%, 97.22% 72.6% and 94.27% respectively and in case of Neoceptine those values
were 106.7% ,58.74%, 57.25%, and 52.71%, 83.43%, and 98.91% respectively. From the
result it was assumed that Calbo 500 and Acical-M have extreme effect, Filwel Silver has
moderate effect and Nutrum Gold & Aristocal D have less effect on the dissolution of
Zantac & Neoceptine. Therefore, the absorbance and bioavailability can be effected in the
presence of Calbo 500, Acical-M and Filwel Silver. So, this supplements shouldn’t
administer with Zantac or Neoceptine. On the other hand Nutrum Gold & Aristocal-D can
be administered with as they have less or no effect on the dissolution. |
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