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Impact of Different types of Multivitamins, Multiminerals, Calcium and Vitamin supplement drugs on dissolution profile of Zantac® & Neoceptine®

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dc.contributor.author Haque, Md. Jahidul
dc.date.accessioned 2016-09-21T03:13:31Z
dc.date.available 2016-09-21T03:13:31Z
dc.date.issued 7/11/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/1823
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The research work was proposed to find out the impact of Acical-M (Calcium, Vitamin & Minerals tablet), Calbo (Calcium supplement tablet), Aristocal D (Calcium & vitamin-D Tablet), Filwel Silver (Multivitamin Silver Tablet) and Nutrum Gold (Multivitamin & Multiminerals Tablet) on the dissolution of Ranitidine (Zantac & Neoceptine). Zantac is parent product of Ranitidine produced by GlaxoSmithKline Bangladesh and Neoceptine is the brand name of Ranitidine produced by Square Pharmaceutical Ltd. To determine the physical parameters of Ranitidine tablet, some important tests such as weight variation test, hardness test and thickness test were performed. The dissolution test was performed by using distilled water (used as dissolution medium) with USP dissolution apparatus II followed by UV Spectroscopy. The dissolution of individual Ranitidine tablets and also with the combination of following supplements, were determined after 20, 40 and 60 minutes. After 60 minute, the percent dissolved amount of individual Zantac and Zantac with Calbo, Acical-M, Filwel Silver , Aristocal D and Nutrum Gold were 94.09%, 47.84%, 48.47%, 97.22% 72.6% and 94.27% respectively and in case of Neoceptine those values were 106.7% ,58.74%, 57.25%, and 52.71%, 83.43%, and 98.91% respectively. From the result it was assumed that Calbo 500 and Acical-M have extreme effect, Filwel Silver has moderate effect and Nutrum Gold & Aristocal D have less effect on the dissolution of Zantac & Neoceptine. Therefore, the absorbance and bioavailability can be effected in the presence of Calbo 500, Acical-M and Filwel Silver. So, this supplements shouldn’t administer with Zantac or Neoceptine. On the other hand Nutrum Gold & Aristocal-D can be administered with as they have less or no effect on the dissolution. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00473
dc.subject Ranitidine, Dissolution, UV-spectroscopy, Distilled water, Absorbance, Dissolution apparatus II. en_US
dc.title Impact of Different types of Multivitamins, Multiminerals, Calcium and Vitamin supplement drugs on dissolution profile of Zantac® & Neoceptine® en_US
dc.type Thesis en_US


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