Abstract:
Purpose: The purpose of this research work was to investigate the release pattern of
Salbutamol Sulphate from two different brands (SULTOLIN@ & SALBUTAL@) of
Bangladesh. Method: Thirty tablets of each brand were collected from the market and
were characterized by physical parameters like hardness, thickness, weight variation and
dissolution studies. Salbutamol Sulphate release was investigated using the method
inscribed in dissolution study part. Dissolution tests for tablets and capsules of British
pharmacopoeia. Hardness of the withdrawn samples from the market was measured by
hardness tester (Veego, Germany). Thickness of the samples was measured by Vernier
Calipers. Fri ability of the samples was measured by using Roche Friability Tester.
Dissolution of the taken samples was investigated using dissolution tester (RC6,
Vanguard Pharmaceuticals, USA) to evaluate release kinetics. Because with the help of in
vitro release data we can also predict the in vivo release as well as bio availability of the
drug. For this purpose stomach like environment was created. Result: Mean hardness
value of Salbutamol (Sultolin; Salbutal) tablets was found to be (9.99; 13.03) N. Mean
thickness value of Salbutamol (Sultolin; Salbutal) tablets was found to be (8.17; 6.32)
cm. Average weight of Salbutamol (Sultolin; Salbutal) was (o.1710; 0.1008). And o% loss
of Salbutamol (Sultolin; Salbutal) was (0.37; -0.10). Conclusion' The release pattern of
Salbutamol Sulphate 4mg tablet did not fulfill its requirement to provide desired and
optimum release of the drug with the increase of time due to prior limitation.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
