In-vitro Comparative Dissolution Study of Different Brands (Alcet, Lecet, Clarigen, Lozin) of Levocetirizine Dihydrochloride, Available in Bangladesh, With Respect to Purotrol

Abstract

The aim of the present study was to evaluate and compare dissolution pattern of locally branded drug products of Levocetirizine 2HCl available in Bangladesh with the brand of Levocetirizine 2HCl (Purotrol) marketed by Square pharmaceutical company. Purotrol is one of the most used drug of Levocetirizine 2HCl. Branded drugs are expensive than locally marketed drug. Substitution of drugs is very essential for the people of under developing country. Four different brands of Levocetirizine 2HCl tablets which are available in Bangladesh like Alcet, Seasonix, Lozin, Clarigen, and Lecet etc. with respect to purotrol were collected from a reputed pharmacy store. Two tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 30 minutes for all the brands. All the brands were compared with Purotrol. Differential factor, f1 and similarity factor, f2 were determined. Significant difference was observed during invitro drug release pattern of local brands with respect to purotrol .Here it was found the values of f1 are 26.08, 15.52, and 25.11 so it is not acceptable. Only Lozin has f1 value less than 15 i.e. (13.7) therefore that is accepted. And the similarity factor it was seen that the values of f2 are 30.77, 44.79, 15.52 and 25.11, so it is also not acceptable. In conclusion, further investigations are needed to evaluate better dissolution study.