Evaluation of Photo-degradation of Alatrol® (Cetirizine Hydrochloride) Under different Extreme lighting Condition: An UV Analysis

Abstract

This work was aimed for the determination of photo-degradation of Cetirizine Hydrochloride. The objective of this study was to determine the effect on Cetirizine Hydrochloride under various extreme lighting conditions which comprised of sunlight, incandescent bulbs of 25watt & 40watt bulb. In normal lighting condition degradation of cetirizine hydrochloride was not reported. Under different extreme lighting conditions potency ceased differently with a percent deviation of 3.67% (1.54%) , 9.34% (2.53%) and 16.58% (3.09 %) respectively for 25 watt,40 watt and direct sunlight respectively. So it can be said that the Alatrol® containing Cetirizine Hydrochloride is light sensitive and coating alone is not sufficient to protect the drug from light. So that package should be opaque thus light cannot pass through the package.