Abstract:
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and the most
predominant cause of dementia in the elderly. Traditionally Pterocarpus santalinus (L.) has
widely known for its medicinal use. Our aim is to investigate the cholinesterase inhibitory
activities, and antioxidant properties of the plant extracts in the treatment of AD. The crude
methanol extract was prepared by cold extraction method and four fractions namely
petroleum ether, chloroform, ethyl acetate, and water fraction were assessed for
acetylcholinesterase and butyrylcholinesterase inhibitory activity by the Ellman method, and
their antioxidant properties were assessed by several assays including reducing power,
scavenging of DPPH and hydroxyl radicals together with quantitative analyses of endogenous
substances. The extracts are found moderately active against the Acetylcholinesterase
enzyme. The results revealed that methanol extract, possibly due to its phenolic compounds,
exerts moderate antioxidant and cholinesterase inhibitory activities which may be useful in
the treatment of AD.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
