Pharmacological Studies of Brihat sarvajvar Har Louha (BSH)

Abstract

T-:is research work describes the Pharmacological Studies of Brihat Sarvajvar Har Louha tsSH) an ayurvedic drug. Five (5) experiments have been carried out so far at different J.r-s (100 mg/kg, 200 ng/kg and 400 mglkg) to find out the various degrees of simificance of action of the drug Brihat Sarvajvar Har T-ouha (BSH) on experimental enimals. The Hole Cross Test resulted in significant (p:0.042) increase in movement in the close arm which indicates that the drug BSH has potent CNS stimulant activity. Acetic Acid Writhing Test also produced a significant decrease (p:0.046) in writhing :--Ponse which indicates that the drug BSH has potent analgesic activity. Xylene induced s.'r edema test has been conceived to study the anti inflammatory effect of a test drug BSH). Xylene Induced Ear Edema Test showed very highly significant (p:0.000) Jecrease in inflammation which indicates that the drug has potent anti inflammatory effect. On the other hand Formalin induced paw licking test has been done to study the analgesic and anti-inflammatory effect of a test drug (BSH). Formalin Test also showed significant (p:0.010) decrease in case of analgesic activity. Hole Board test has been done to determine the stimulatory or depressive effect of test drug (BSH). Open field test has been carried out to determine the stimulatory or depressive effect of test drug (BSH), b1' determining the ambulatory, emotional defecation, central ambulation and standing behavior of mice. These two experiments resulted in no significant observations but there have been overall decreases or increases in activities in different experiments in comparison to respective control groups. From the findings of the experiments we can conclude that this drug (BSH) has analgesic and antipyretic activity and has minimal side effects.