Abstract:
Purpose: The objective of this research work was to evaluate the relationship between
hardness and in vitro release profile of different brands of Indapamide(SR) tablet
available in Bangladesh. Method: Three different brands of Indapamide(SR) tablets
namely Repress(SR), Hypen(SR) and Indapa(SR) marketed by Square Pharmaceuticals
ltd. Opsonin Pharma Ltd and Drug International respectively were collected from the
market and evaluated the hardness and dissolution profile of these tablets. The release
profile of Indapamide(SR) was investigated by using the method inscribed in Appendix
XII B: Dissolution tests for tablets and capsules of British Pharmacopoeia. Hardness of
these tablets were measured by"hardness tester (Veego, Germany) and dissolution of the
taken samples were investigated using (RC6, Vanguard Pharmaceuticals, USA)
dissolution tester to evaluate the relationship between the hardness of the tablet and the
rate of dissolution. Result: The mean hardness value of the Indapamide(SR) tablets were
found. Repress(SR) 110.37 N, Hypen(SR) 59.91 Nand Indapa(SR) 15.09 N and the rate
of dissolution of these different brands of Indapamide was found Repress(SR) 0.00016
mg. ml , Hypen(SR) 0.00018 mg/ml and Indapa(SR) 0.0018 mg/ml when the absorbance
\\as measured at 275 nm. Conclusion: There is a direct relation between the hardness of
the tablet and the rate of dissolution. The dissolution rate was inversely proportional to
the hardness of the tablet.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
