Abstract:
This work was proposed to assess the compatibility of Actives viz. Albendazole, Levofloxacin and Pregabalin with different functional excipients like fillers/diluents, disintegrants, binders and lubricants which are commonly used in solid dosage formulation. Samples were made by mixing active and excipients in different ratio and put in stability chamber at different stability conditions. Samples were withdrawn at different time intervals and tested accordingly. Assay, Impurity and IR spectrum were chosen as testing parameter to determine the compatibility of actives with particular excipient. This research work has demonstrated the relationship between active and excipients and their compatibility in dosage form formulation. Tentative formula of the dosage forms viz. Albendazole Chewable Tablets, Levofloxacin Film Coated Tablets and Pregabalin Capsules were also established and evaluated.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.
