Pharmacological Studies of Dhatri Lauha

Abstract

DHATRI LAUHA is a widely used formulation in folk and ayurvedic systems of medicine and it is commonly used for Sularoga (colic), pandu (anaemia) , kamala (jaundice), amlapitta (hyperacidity non ulcer dyspepsia). This ayurvedic drug mainly formulated of Dhatri (amalaki) cuma, Lauha cuma (bhasma), Yastimadhuraja (cuma), Amrta kvatha and these compounds are already well tested for their various types of therapeutic action and in certain diseases. In addition to mixture of these compound taken with ghee and honey for their optimum therapeutic activity. Total 9 experiments were carried out at different doses (100, 200 and 400 mg/kg, p.o.) of DHATRI LAUHA which studied in different animal model to find out the various degrees of significance of action of the drug on experimental animals. Highly significant (p=0.009) increase in ambulation behavior was observed in Hole board test. In Hole cross test highly significant (p=0.005) increase in motor activity was observed. Open field test showed significant (p=0.036) increase in Standing up behavior. Climbing out test produced a significant (p=0.039) decrease in activity. None of the other experiments resulted in significant observations but there have been overall decreases or increases in activities in different experiments in comparison to respective control groups. All these experiment were executed in an attempt to confirm the safety of the general patients or users of the society and country as a whole. After completion of this research work now we can suggest that this DTR can be prescribed for treating different diseases without or with a minimal central nervous system side-effect. It also found that the drug has no effect on the gut motility and gastric emptying time.