Study of Pharmacological activities of methanolic extract of Jatropha gossypifolia fruits

Abstract

Purpose: The research work was carried out to determine the pharmacological activities of methanolic extract of Jatropha gossypifolia fruits. Method: Methanolic fruit extract was administered orally to the animal model (Swiss albino) and the effects were determined by comparing with respect to control group which were treated with 1% Tween 80 in saline. For every experiment positive control was used. Different experiments were used to determine the pharmacological profile which was collected from internationally published publications and journals. Result: Oral administration of fruit extract of J. gossypifolia was found to decrease the writhing response which was very highly significant (p<0.001). In brine shrimp lethality bioassay the lowest LC50 values was found 2.84 g/ml. A very highly significant (p<0.001) antidiarrheal activity was found in the sample. The percentage of protection of the diarrheal stool by the extract at the doses 200 mg/kg body weight was 61.11%. In hole cross test, two data were very highly significant (p<0.001) and three were highly significant (p<0.01). Three noticeable data were observed in hole board test which were very highly significant (p<0.001). A significant (p<0.5) difference was found in grooming and time spent in open arm in elevated plus maze test compared to control. Conclusion: After summarize all the results it can say that fruit of Jatropha gossypifolia may have several pharmacological activities but to prove the hypothesis it need further higher studies.