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Drug - Drug Interaction study of Atorvastatin in combination by comparative in vitro dissolution

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dc.contributor.author Islam, MD. Samiul
dc.date.accessioned 2014-06-29T04:09:30Z
dc.date.available 2014-06-29T04:09:30Z
dc.date.issued 12/6/2013
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/677
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The purpose of this research work was to determine if there is any drug drug interaction in case of combination drugs taken with Atorvastatin at same time by comparative in-vitro dissolution study. Single dose of Atorvastatin was the standard to compare with other drugs taken at the same time with Atorvastatin. The other drugs that was given with Atorvastatin at the same time, selected by sorting out prescriptions of different cardiovascular patients from different hospitals. Some prescriptions were selected where a patient has to administer Atorvastatin with Sedil® Nidocard® twice daily. So with the dissolution test we can determine the %dissolved of drug hence its bioavailability and to see if there was any interaction with other drugs to increase or decrease %dissolved and bioavailability. The dissolution rate was determined in phosphate buffer pH6.8 using paddles at a speed of 75 rpm. The dissolution assay was determined through UV analysis at maximum wavelength of 242nm respectively. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00331
dc.subject Atorvastatin calcium, Dissolution test en_US
dc.title Drug - Drug Interaction study of Atorvastatin in combination by comparative in vitro dissolution en_US
dc.type Thesis en_US


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