Abstract:
This experiment describes in vitro evaluation of Metronidazole immediate release
tablet. Drug release study was evaluated for 75 minutes using United State
Pharmacopeia (USP), paddle type (type-2) dissolution apparatus using 0.1 N Hel as
the dissolution medium. The release mechanisms were explored and explained with
zero order, first order, Hihuchi equations, and Korsmeyer equation. The content of
active ingredient was a vital factor in controlling drug release pattern. It was found
that after 75 minutes better market preparation Metronidazole maximum released. In
this experiment various types of Metronidazole market preparations were used. Their
other physical parameters were also studied. Generally, dissolution test is applied to
evaluate various formulations for the selection of an optimum one. For this purpose,
dissolution parameters are varied to investigate a method that can predict oral rate of
absorption of metronidazole.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
