Investigation of Different Pharmacokinetic Parameters along with in-vitro Dissolution Study of Metronidazole Immediate Release Tablets of Various Market Preparations Available in Bangladesh

Abstract

This experiment describes in vitro evaluation of Metronidazole immediate release tablet. Drug release study was evaluated for 75 minutes using United State Pharmacopeia (USP), paddle type (type-2) dissolution apparatus using 0.1 N Hel as the dissolution medium. The release mechanisms were explored and explained with zero order, first order, Hihuchi equations, and Korsmeyer equation. The content of active ingredient was a vital factor in controlling drug release pattern. It was found that after 75 minutes better market preparation Metronidazole maximum released. In this experiment various types of Metronidazole market preparations were used. Their other physical parameters were also studied. Generally, dissolution test is applied to evaluate various formulations for the selection of an optimum one. For this purpose, dissolution parameters are varied to investigate a method that can predict oral rate of absorption of metronidazole.