Formulation and Evaluation of Diclofenac 12H SR Matrix from Hydrophilic Polymer

Abstract

The study was done to evaluate six fonnulations of Diclofenac Sodium SR 12H incorporated with two different polymers ( Methocel K 15 MCR & Methocel 1 00 LV CR). The polymers played an important role upon the % drug release. The fonnulations (F-l to F-6) polymer ratio was (1:5, 3:4, 2:5, 4:3, 3:3, 3:5). The fonnulations F-3 & F-6 fulfill the official requirements in 2 hour is simulated acidic (PH 1.3) and 8 hour in buffer (PH 6.8). Dissolution was done by USP reference dissolution apparatus .The physical evaluation such as bulk density, compressibility index, angle of repose, total porosity, hausner ratio, hardness & friability test, thickness, weight variation test was also done. In vitro drug release profile was extra cloated by drug release kinetics Zero order and First order equation.