Abstract:
In the entitled study, an effort has been delivered to develop once daily-sustained release
matrix tablets of diclofenac. The design of Diclofenac SR tablet (NSAID), a cyclooxygenase
inhibitor is to achieve more patient compliance. To prepare tablets of our desired formulation
direct compression method were followed which easier and less time is consuming. Since the
study concerns with the development of sustained release matrix tablet, a high viscosity and molecular weight (MW>300) of polymer were used. Several ratios ofmethocel K15 M CR &
KlOO LVCR (hydrophilic polymer) were used as rate retarding materials. Before
compressing the tablets, the granules of different proposed formulations (F-I to F -9) were
e\'aluated for LBD (0.40-0.435 glml), TBD (0.625-0.69 glml), % Compressibility Index
430.4-40.03), Total Porosity, Angle of Repose (46.85°-68.96°), Hausner Ratio (1.44-1.90) md % Total Porosity (20.35-30.87 %). The tablets were subjected to thickness, Diameter,
~ght variation test, hardness and friability test. Depending upon the values of angle of
repose and % compressibility index, the granules show poor flow properties. While according
ID banner ratio formula F-8 (1.44) shows moderate flow property. In the designing of
trained release product, the physical evaluations alone do not indicate a good % release of
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
