Abstract:
This research work was conducted to describe the coating efficiency on photolytic degradation of Tenoren® (Atenolol). The objective of this study was to determine the reproducibility of the effect of Atonolol in various lighting conditions (control, sunlight, normal room light, 25watt & 40watt bulb). UV spectrophotometer was used for measuring the absorbance. Besides, physical tests were performed for evaluation of color change, weight variation, thickness and hardness of the Tenoren® tablets from same batch. Physical tests were performed according to the specification of USP and the standard deviation of weight variation, hardness and thickness were ±0.00020 g, ±0.36250 kg & ±0.01725 mm respectively .But it was also observed that the concentration of Atenolol was decreased gradually in various light condition (25watt & 40watt electrical bulb, sunlight, normal light) and at 25watt, 40watt, direct sunlight and normal room light exposure the degradation were observed 12.55%, 15.30%, 25.96% & 9.74% respectively. So, it can be said that coating alone was not sufficient to protect the drug from light.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh.
