Determination of Variation in Flow Property of Different Formulas of Calcium phosphate along with Amlodipine and Propranolo

Abstract

This work was proposed to determine the flow properties of different set of some important pharmaceutical excipients along with APIs that are most commonly used to search some equations which can predict the flow property of any set of excipients and APIs with different ratio of diluent. Different parameters to determine flow property such as Compressibility index, Hausner ratio, and angle of repose were observed for them. Many unique formulas were equipped by choosing various excipients from different classes. Diluents were mixed with these prepared formulas in different specific and justified ratio. The prepared mixture in a constant weight was then examined for measuring flow property. I also used APIs to determine the difference in flow property. The values of Carr’s index, Hausner ratio and angle of repose were plotted against the percentage ratios of diluent. The study showed a linear relationship with different ratios of mixture and flow property measuring parameters. From these graphs the straight-line equations for each set of formula were obtained with regression value close to 1 which can be used to predict the flow property of these formula with different ratio of diluents. Moreover the most suitable ratio of specific diluent and a specific set of excipients along with APIs were proposed that showed better flow property.