Determination of Variation in Flow property of Different Formulas of magnesium Stearate along with Amlodipine and propranolol

Abstract

This work was performed to determine flow properties of different set of some important pharmaceutical excipients that are most commonly used for the directly compressible tablets, dry powders, powder for suspensions etc. This study was also done to search for some equations which can predict the flow property of any set of excipients with different ratio of anti adherent (Mg stearate) along with propranolol and amlodipine. Different parameters to determine flow property such as Compressibility index, Hausner ratio, and angle of repose were observed for them. Anti adherent was mixed with these prepared formulas in different specific and justified ratio. The values of Carr‟s index, Hausner ratio and angle of repose were plotted against the percentage ratios of anti adherent. The study showed a linear relationship with different ratios of mixture and flow property measuring parameters. From these graphs the straight-line equation for each set of formula were obtained. Moreover the most suitable ratio of anti adherent and a specific set of other excipients were proposed that showed better flow property.