Abstract:
Oxidative stress and low amount of neurotransmitter specially acetylcholine are
main characteristics of Alzheimer’s disease (AD), which is a progressive neurodegenerative disease. Prolonging the function of acetylcholine by inhibiting
acetylcholinesterase or butyrylcholinesterase enzyme and reducing oxidative
stress with antioxidants are effective treatment therapy of AD. Tamarindus
indica is a well-known medicine plant with a variety of medicinal uses. In this
study we examined cholinesterase inhibitory activity and antioxidant activity of
tamarind leaf and bark extract. Cholinesterase inhibitory activity with IC50 of
188.67 μg/ml and 176.30 μg/ml for acetylcholinesterase and butyrylcholinesterase enzyme respectively suggested that it possesses a good source of enzyme inhibitor. In conclusion, we can say Tamarindus indica provide not only Cholinesterase inhibitory activity but also antioxidant activity which can be useful for further research to get potential molecule from it.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
