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In-Vitro Evaluation of Cholinesterase Inhibitory and Antioxidant Activities of Tamarindus indica for the Treatment of Alzheimer’s Disease

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dc.contributor.author Rahman, Md. Ashiqur
dc.date.accessioned 2016-09-21T03:13:05Z
dc.date.available 2016-09-21T03:13:05Z
dc.date.issued 5/11/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/1814
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract Oxidative stress and low amount of neurotransmitter specially acetylcholine are main characteristics of Alzheimer’s disease (AD), which is a progressive neurodegenerative disease. Prolonging the function of acetylcholine by inhibiting acetylcholinesterase or butyrylcholinesterase enzyme and reducing oxidative stress with antioxidants are effective treatment therapy of AD. Tamarindus indica is a well-known medicine plant with a variety of medicinal uses. In this study we examined cholinesterase inhibitory activity and antioxidant activity of tamarind leaf and bark extract. Cholinesterase inhibitory activity with IC50 of 188.67 μg/ml and 176.30 μg/ml for acetylcholinesterase and butyrylcholinesterase enzyme respectively suggested that it possesses a good source of enzyme inhibitor. In conclusion, we can say Tamarindus indica provide not only Cholinesterase inhibitory activity but also antioxidant activity which can be useful for further research to get potential molecule from it. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00457
dc.subject Alzheimer’s Disease en_US
dc.title In-Vitro Evaluation of Cholinesterase Inhibitory and Antioxidant Activities of Tamarindus indica for the Treatment of Alzheimer’s Disease en_US
dc.type Thesis en_US


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