Impact of Different Supplement Drugs on the Dissolution Profile of Zantac® & Ranitid®

Abstract

The objective of the research work was to investigate the impact of Calbo®500mg(Calcium supplement tablet), Acical-M (Calcium, Vitamin & Minerals tablet), Aristocal D (Calcium & vitamin-D Tablet), Filwel Silver (Multivitamin Silver Tablet) and Nutrum Gold (Multivitamin & Multimineral Tablet) on the dissolution of Ranitidine (Zantac® & Ranitid®). Zantac® is a patent product of Ranitidine produced by Glaxosmithkline Bangladesh and Ranitid® is the brand name of Ranitidine produced by Opsonin Pharmaceutical Ltd. The physical parameters of Ranitidine tablets were determined by performing weight variation test, hardness test and thickness test. The dissolution test was performed by using distilled water (used as dissolution medium) with USP dissolution apparatus II followed by UV Spectroscopy. A standard curve equation of Ranitidine was established for the calculation of percent dissolved amount of drug. The dissolution of individual Ranitidine (Zantac® & Ranitid®) tablets and also in combination with the following supplement drugs, were determined after 20, 40 and 60 minutes. After an hour, the percent dissolved amount of individual Zantac®, Zantac® with Calbo®500, Zantac® with Acical-M, Zantac® with Aristocal D, Zantac® with Filwel Silver and Zantac® with Nutrum Gold were 94.09%, 47.84% , 48.47%, 72.6%, 97.22% and 94.27% respectively and in case of Ranitid®, those values were 91.89%, 49.79%, 51.18%,70.95%, 98.91% and 95.67% respectively. From the result it was assumed that Calbo® 500 and Acical-M has extreme effect on the dissolution of Zantac® and Ranitid®, Aristocal D has moderate effect for both Zantac® and Ranitid®. So these three supplements cannot be co-administered with Zantac® and Ranitid®. The dissolution of Zantac® and Ranitid® were not decreased by Nutrum Gold or Filwel Silver (Multivitamin and multimineral). As Nutrum Gold and Filwel Silver were not decreased the dissolution of Zantac® and Ranitid®, this supplement drugs can be coadministered with Zantac® or Ranitid®.