Drug Discovery Targeting Proteomic Approach

Abstract

The drug discovery process is not a limited or established series of steps. Modern approaches include target-based drug discovery in which researchers require to survey proteins. The two most important requirements for this type of technology are to find more effective biomarkers for detecting disease and to discover proteins to which therapeutic drugs can be targeted. It is well-known that the risks in drug discovery process are high and it requires a great deal of time before it is known whether a target candidate drug will succeed or fail. The key to success for pharmaceutical companies is to make accurate decisions using an accelerated process. Genomics revolution had a very positive impact upon these issues. Proteomics is in the field, now, as a powerful new partner of genomics. It will provide a significant new aspect to drug discovery by providing the potential to analyze proteins from a very wide diversity of biological systems in a high-throughput and systematic way. Each step of the process from target discovery to clinical trials is accessible to proteomics. Scientists are able to see every detail of their biological focus, from genes, mRNA, proteins and their subcellular localization. This will greatly help our knowledge of the fundamental mechanistic basis of human disease and will assist in the discovery of improved, faster, minimum toxic and hopefully, inexpensive drugs.