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Comparative Analysis of In Vitro Release Kinetics of Sultolin® and Salbutal®

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dc.contributor.author Shamsunnaher
dc.date.accessioned 2016-11-24T05:37:36Z
dc.date.available 2016-11-24T05:37:36Z
dc.date.issued 12/24/2009
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/1975
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract Purpose: The purpose of this research work was to investigate the release pattern of Salbutamol Sulphate from two different brands (SULTOLIN@ & SALBUTAL@) of Bangladesh. Method: Thirty tablets of each brand were collected from the market and were characterized by physical parameters like hardness, thickness, weight variation and dissolution studies. Salbutamol Sulphate release was investigated using the method inscribed in dissolution study part. Dissolution tests for tablets and capsules of British pharmacopoeia. Hardness of the withdrawn samples from the market was measured by hardness tester (Veego, Germany). Thickness of the samples was measured by Vernier Calipers. Fri ability of the samples was measured by using Roche Friability Tester. Dissolution of the taken samples was investigated using dissolution tester (RC6, Vanguard Pharmaceuticals, USA) to evaluate release kinetics. Because with the help of in vitro release data we can also predict the in vivo release as well as bio availability of the drug. For this purpose stomach like environment was created. Result: Mean hardness value of Salbutamol (Sultolin; Salbutal) tablets was found to be (9.99; 13.03) N. Mean thickness value of Salbutamol (Sultolin; Salbutal) tablets was found to be (8.17; 6.32) cm. Average weight of Salbutamol (Sultolin; Salbutal) was (o.1710; 0.1008). And o% loss of Salbutamol (Sultolin; Salbutal) was (0.37; -0.10). Conclusion' The release pattern of Salbutamol Sulphate 4mg tablet did not fulfill its requirement to provide desired and optimum release of the drug with the increase of time due to prior limitation. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00006
dc.subject salbutamol Sulphate, Dissolution, Hardness, Thickness, Friability' Stomach, Release Pattern. en_US
dc.title Comparative Analysis of In Vitro Release Kinetics of Sultolin® and Salbutal® en_US
dc.type Thesis en_US


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