Pharmacological Studies of an Ayurvedic Preparation, Sukramatrika Vati

Abstract

Purpose: The research was carried out in order to study the pharmacological aspects and possible side effects of the marketed cost-effective Ayurvedic formulation, Sukramatrika Vati mainly indicated for the treatment of urolithiasis; based on analgesic, neuropharmacological and gastrointestinal effects on animal models. Method: The research project was conducted using five previously established pharmacological models proposed by various scientists. The experiments were executed at three dose levels of lOa mg/kg, 200 mg/kg and 400 mg/kg on animal models (Swiss albino) in order to determine the various degrees of significance on activity resulted by Sukramatrika Vati ResutI: Sukramatrika Vati treated mice at dose 100 mg/kg showed a decrease in writhing response in the 2nd minute which was statistically significant (p = 0.047). In addition, the overall -reduction in pain perception from minutes 1 to 5 was found to be statistically significant (p = 0.043). In the hole board test, at the dose of 200mg/kg, the reduction in emotional defecation at minute 240 was observed to be statistically significant (p = 0.044). Apart from these, . sukramatrika Vati treated m ice at the dose of 400mg/kg showed an overall decrease in ambulation in the open field test. The results obtained at minute 60 and 120 were statistically - -highly significant (p = 0.004) and (p = 0.004). The reading obtained at minute 180 was also statically significant (p = 0.0 I 0). Conclusion: The findings of the experiments on the animal models show that possibly sukrmatrika Vati may act as a useful analgesic for the palliative treatment of urolithiasis. addition, the results show that the preparation probably also possesses no anxiogenic effects. Further studies using sophisticated models need to be performed to fully fathom the safety ofsukmatrika Vati for Alternative Medical Care .