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Impact of Calcium and Vitamin D supplement on the Dissolution Profile of RosuvaTM (Rosuvastatin)

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dc.contributor.author Nova, Jannatul Ferdous
dc.date.accessioned 2017-06-13T04:12:38Z
dc.date.available 2017-06-13T04:12:38Z
dc.date.issued 12/12/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2186
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The objective of the research work was to investigate the impact of Calcium and Vitamin D supplement on the dissolution profile of RosuvaTM 10 mg (Rosuvastatin Calcium) tablet. The dissolution test was performed by using distilled water (as dissolution medium) with USP dissolution apparatus II. The amounts of drugs released were measured using UV spectroscopy. A standard curve equation of Rosuvastatin was established for the calculation of percent dissolved amount of drug. The dissolution of individual Rosuvastatin (RosuvaTM 10 mg) tablets and also combination with the Calcium and Vitamin D supplement drugs were determined after 10, 20, 30, 40, 50, 60 minutes. Six samples of each individual Rosuvastatin (RosuvaTM 10 mg) tablets and combination with the Calcium and Vitamin D supplement drugs were subjected to determine the dissolution profile. After an hour the average percent dissolved amount of individual Rosuva and Rosuva with Calcium and Vitamin D supplement were respectively 71.13% and 50.25%. From the result it was assumed that Calcium and Vitamin D supplement has extreme effect on the dissolution of Rosuva. The dissolution rate of Rosuva was decreased by the effect of Calcium and Vitamin D supplement may be due to the common-ion effect. As Calcium and Vitamin D supplement has the extreme effect on the dissolution profile of Rosuvastatin Calcium, they should not be used concomitantly. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00533
dc.subject UV spectroscopy, USP dissolution apparatus II, Hardness, Thickness, Weight variation, Dissolution impact, Common-ion effect en_US
dc.title Impact of Calcium and Vitamin D supplement on the Dissolution Profile of RosuvaTM (Rosuvastatin) en_US
dc.type Thesis en_US


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