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Impact of Calcium & Vitamin D Supplement on the Dissolution Profile of Ropitor

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dc.contributor.author Taki, Tasnim Kabir
dc.date.accessioned 2017-06-13T04:15:49Z
dc.date.available 2017-06-13T04:15:49Z
dc.date.issued 12/22/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2214
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The objective of the research work was to investigate the impact of Calvimax-D® (Calcium supplement tablet), on the dissolution of Rosuvastatin (Ropitor®). During research, we took the Ropitor® as main which is a patent product of Rosuvastatin manufactured by Opsonin Pharmaceutical Ltd and Calvimax-D which is apatent product of Incepta Pharmaceutical Ltd . My project was to determine the impact of calcium and Vitamin D supplement on the dissolution profile of Ropitor. To finding out the target , we performed some essential in vitro test such as dissolution test, dissolution of Ropitor individually and in combination with Calvimax-D. The physical parameters of Ranitidine tablets were determined by performing weight variation test, hardness test and thickness test. The dissolution test was performed by using distilled water (used asdissolution medium) with USP dissolution apparatus II followed by UV Spectroscopy.A standard curve equation of Rosuvastatin was established for the calculation of percent dissolved amount of drug. The dissolution of individual Rosuvastatin( Ropitor®) tablets and also in combination with the calcium supplement drug Calvimax-D® ( Calcium and Vitamin D) were determined after 10, 20, 30,40 , 50 and 60 minutes. After an hour, the percent release of individual Ropitor® was found between 46.05 % to 71.46% and the percent release of Ropitor® with Calvimax-D® were between 38.08% to 61.01%. After that the impact of supplement drug on the dissolution of Ropitor had been determined. From the result it was assummed that if the dissolution of Ropitor is affected due to the impactof Calvimax-D (Calcium and Vitamin D) then we should avoide administration of that supplement drug with Ropitor. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00549
dc.subject UV Spectroscopy, USP dissolution apparatus II, Hardness, Thickness, Weight Variation, Dissolution Impact en_US
dc.title Impact of Calcium & Vitamin D Supplement on the Dissolution Profile of Ropitor en_US
dc.type Thesis en_US


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