Abstract:
Citrus fruits are well known for its antioxidant properties. Alzheimer’s disease (AD),
a common type of progressive neurodegenerative disease, is characterized by low
level of neurotransmitter (acetylcholine), oxidative stress and neuro-inflammation in
brain stream. Effective treatment strategies rely mostly on either enhancing the
cholinergic function of the brain by stimulating the cholinergic receptors, improve the
level of acetylcholine from being a breakdown by cholinesterase enzymes or induce
antioxidant therapy. . Beside this atherothrombosis is a major cause of global life
threatening cerebral diseases. In this study we examine five commonly available
Citrus fruits available in Bangladesh; those are well known for their antioxidant
activities with a rich source of vitamin C and polyphenols. A crude methyl extract
(CME) of these fruits are evaluated for acetylcholinesterase (AChE) and
butyrylcholinesterase (BuChE) inhibitory activity by Ellman’s method. Antioxidant,
free radical scavenging, reducing power and thrombolytic property are also assessed
in this study, which strongly implies that that the CME of these fruit are of AChE and
BuChE inhibitors with moderate thrombolytic activities.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh
