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A Comparative Assessment of Five Available Citrus Fruits’ Cholinesterase Inhibitory, Antioxidant and Thrombolytic Activities for the Treatment of Neurodegenerative Disorders

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dc.contributor.author Rika, Shanjida Alam
dc.date.accessioned 2017-06-13T04:16:53Z
dc.date.available 2017-06-13T04:16:53Z
dc.date.issued 12/25/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2217
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh en_US
dc.description.abstract Citrus fruits are well known for its antioxidant properties. Alzheimer’s disease (AD), a common type of progressive neurodegenerative disease, is characterized by low level of neurotransmitter (acetylcholine), oxidative stress and neuro-inflammation in brain stream. Effective treatment strategies rely mostly on either enhancing the cholinergic function of the brain by stimulating the cholinergic receptors, improve the level of acetylcholine from being a breakdown by cholinesterase enzymes or induce antioxidant therapy. . Beside this atherothrombosis is a major cause of global life threatening cerebral diseases. In this study we examine five commonly available Citrus fruits available in Bangladesh; those are well known for their antioxidant activities with a rich source of vitamin C and polyphenols. A crude methyl extract (CME) of these fruits are evaluated for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity by Ellman’s method. Antioxidant, free radical scavenging, reducing power and thrombolytic property are also assessed in this study, which strongly implies that that the CME of these fruit are of AChE and BuChE inhibitors with moderate thrombolytic activities. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00551
dc.subject Neurodegenerative Disorders en_US
dc.title A Comparative Assessment of Five Available Citrus Fruits’ Cholinesterase Inhibitory, Antioxidant and Thrombolytic Activities for the Treatment of Neurodegenerative Disorders en_US
dc.type Thesis en_US


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