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Antimicrobial and Cytotoxic Investigations of Petroleum ether Extract of Dracaena spicata

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dc.contributor.author Nazneen, Sumona
dc.date.accessioned 2017-06-13T04:18:11Z
dc.date.available 2017-06-13T04:18:11Z
dc.date.issued 12/19/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2230
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh en_US
dc.description.abstract Dracaena spicata has been used as a medicinal plant for the general promotion of health and longevity by Asian tribal. It is used as a traditional medicine for the treatment of various diseases like cough, syphilis, conjunctivitis, constipation, boils, eczema, scabies, septic abscess, itching and skin allergy, burns, chicken pox, warts and leucoderma, fungal and bacterial infections, including healing cuts and wounds has been documented by randomly interviewing Chakma, Marma and Tanchunga tribes of the hill tracts districts of Bangladesh since 1995. The aim of the present study was to evaluate the antimicrobial activity and cytotoxic activity of petroleum ether extract of Dracaena spicata. The antimicrobial activities of petroleum ether solvent extract of Dracaena spicata plant were tested against the gram-positive (Bacillus sereus, Bacillus megaterium, Staphylococcus aureaus) and gram-negative bacterial (Pseudomonas aureaus, Salmonella paratyphi, Salmonella typhi, Vibrio parahemolyticus, Vibrio mimicus, Sheigella dysenteriae, Escherichia coli) strains by observing the zone of inhibition. The antimicrobial test was performed by disc diffusion method. The crude petroleum ether extract of Dracaena spicata plant showed strong (9mm-31mm) antimicrobial activities against the microorganisms .Petroleum ether extract of Dracaena spicata showed very good activity against Bacillus sereus (31 mm) and no activity was found against Bacillus megaterium , Vibrio parahemolyticus .The cytotoxic activity of the plant was done by using Artemia saline Leach. The LC50 was observed approximately as 31.9845 μg/mL with a R2 value of 0.86836., which revealed mild to moderate cytotoxic activity. In conclusion, further investigations are needed to identify the active constituents and the exact mechanism(s) of action responsible for the reported antimicrobial and cytotoxic properties of Dracaena spicata. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00560
dc.subject Dracaena spicata, Antimicrobial, Cytotoxicity , Artemia saline Leach en_US
dc.title Antimicrobial and Cytotoxic Investigations of Petroleum ether Extract of Dracaena spicata en_US
dc.type Thesis en_US


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