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“In Vitro Pharmacological Investigations on Dichloromethane (DCM) Fraction of Sygyzium Samarangense Leaf Extract”

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dc.contributor.author Mustafa, Sadia Afreen
dc.date.accessioned 2017-06-13T04:18:22Z
dc.date.available 2017-06-13T04:18:22Z
dc.date.issued 12/27/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2235
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh en_US
dc.description.abstract The study was designed for pharmacological investigation of dichloromethane (DCM) fraction of methanol extract of the leaves of Syzygiumsamarangense(Family: Myrtaceae). The powdered leaves of Syzygiumsamarangensewere extracted with methanol and then partitioned with nhexane, dichloromethane and ethyl acetate consecutively. The DCM fraction remaining was investigated for total flavonoid content, total phenol content,brine shrimp lethality test and antimicrobial test. The fraction contained 21.073 mg AAE/gm of dried extract in total phenolic content assay and 0.581mg quercetin/gm of dried extract in total flavaniod content assay. Screening for cytotoxic properties using brine shrimp lethality bioassay with tamoxifen (LC50 value of 13.38μg/ml) as positive control showed that the fraction have considerable cytotoxic potency exhibiting LC50 value 2.00 μg/ml. In antimicrobial activity investigation, the DCM fraction showed low to moderate antibacterial and antifungal activity against the tested organisms compared to ciprofloxacin that was used as positive control. The DCM fraction showed strong cytotoxic activity, low antioxidant activity and low to moderate antimicrobial activity. Further investigations are needed for the proper identification and isolation of these bioactive compounds to produce safer drugs for treatment of harmful diseases en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00565
dc.subject Syzygiumsamarangense, Brine shrimp lethality bio-assay, phenolic content, flavonoid content, antimicrobial activity. en_US
dc.title “In Vitro Pharmacological Investigations on Dichloromethane (DCM) Fraction of Sygyzium Samarangense Leaf Extract” en_US
dc.type Thesis en_US


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