Abstract:
Our present studies were focused on the probable anti-diabetic activity of the plant Acacia
Nilotica in laboratory animals and the statistical significance of such effect. The plant extract was
subjected to anti-diabetic study through assessing Disaccharidase activity and six segment
method which was performed to assess the amount of sucrose remaining in the GIT at six
different positions. In Six Segment test, the amount of sucrose unabsorbed in different GIT
segments were evaluated in control rats vs. rats fed with 100mg/kg extract at 30 minutes, 1hour,
and 2hour. In Dissacharidase activity the amount of unabsorbed sucrose in Pancreatic Enzymes
are evaluated in control rats vs rats fed with 100mg/kg extract .The extract caused a significant
(p<0.05), dose dependent inhibition of glucose absorption and showed hypoglycemic effects in
Long-Evans rats weighing about 100-200 gm. The anti-diabetic effects were estimated by
measuring the amount of glucose in the samples collected after the experiment. In conclusion,
these observations provide evidence and possible mechanisms of action for the anti-diabetic
properties of plant Acacia Nilotica claimed in Ayurveda medicine
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
