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In-vitro Comparative Dissolution Study of Different Brands (Alcet, Clarigen, Lecet, Lozin) of Levocetirizine Dihydrochloride with respect to Seasonix

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dc.contributor.author Zahid, Md. Iqbal Hossen
dc.date.accessioned 2017-10-08T06:32:34Z
dc.date.available 2017-10-08T06:32:34Z
dc.date.issued 7/29/2017
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2354
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The aim of the present study was to evaluate and compare dissolution pattern of locally branded drug products of Levocetirizine Dihydrochloride available in Bangladesh with the brand of Levocetirizine Dihydrochloride (seasonix) marketed by Incepta Bangladesh Ltd. Seasonix is one of the renowned antihistamine drug of Bangladesh. Branded drugs are expensive than locally marketed drug. Substitution of drugs is very essential for the people of under developing country. Four different brands of Levocetirizine tablets which are available in Bangladesh like Alcet, Lecet, Lozin,Clarigen as well as Seasonix were collected from a reputed pharmacy store. Two tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 50 minutes for all the brands. All the brands were compared with the reference brand (Seasonix). Differential factor,f1and similarity factor, f2 were determined. No significant difference was observed during in-vitro drug release pattern of brandAlcet, Lecet, Lozin, Clarigenwith the reference brand. Here it was found the values of f1 are 12.19, 2.9, 4.9 and 33.10 but here range is 0-15 acceptable. And the similarity factor it was seen that the values of f2 are 49, 73.87, 25.47 and 69.82. So it is acceptable.In conclusion, further investigations are needed to evaluate better dissolution study. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;00599 PHA
dc.subject Dissolution, Levocetirizine Dihydrochloride, Generic brand, Reference drug product, Differential Factor, Comparative dissolution, In-vitro drug dissolution study en_US
dc.title In-vitro Comparative Dissolution Study of Different Brands (Alcet, Clarigen, Lecet, Lozin) of Levocetirizine Dihydrochloride with respect to Seasonix en_US
dc.type Thesis en_US


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