EWU Institutional Repository

Photo-degradation Study of Dilgard (Carvedilol) using UV-Spectroscopy

Show simple item record

dc.contributor.author Pranty, Abida Islam
dc.date.accessioned 2017-10-10T04:49:42Z
dc.date.available 2017-10-10T04:49:42Z
dc.date.issued 8/3/2017
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2359
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The study was aimed for the determination of photolytic degradation of carvedilol tartrate. The objective of this research was to determine the effect on carvedilol in various lighting conditions (control, sunlight, normal room light, 25watt & 40watt bulb). Besides, physical tests were performed for evaluation of color change, weight variation, thickness and hardness of Dilgard 6.25 mgtablets from same batch according to the specification of USP. A very insignificant fluctuation in result was observed for weight variation, hardness & thickness test.The average weight of tablets was 0.1325gm and it showed negligible fluctuation with ±0.0004. But in various lighting condition like 25watt bulb, 40watt bulb, direct sunlight and normal room light the concentration of carvedilol tartrate were decreased gradually with percent deviation 4.91%, 3.98%, 2.80%, and 23.04 % respectively. Overall this study was done by the UV- spectroscopy analytical method.So it can be said that the Dilgard 6.25 mg tabletscontaining carvedilol is light sensitive and coating alone is not sufficient to protect the drug from light. So that package should be opaque thus light cannot pass through the package. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;00603 PHA
dc.subject Carvedilol Tartrate, Photolytic Degradations, UV-Spectroscopy, Batch, Weight variation, Potency, USP. en_US
dc.title Photo-degradation Study of Dilgard (Carvedilol) using UV-Spectroscopy en_US
dc.type Thesis en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account