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Photo Degradation Study of Cavelon® (Carvedilol) Using UV-Spectroscopy

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dc.contributor.author Mohammadi, Aziza
dc.date.accessioned 2017-10-10T04:56:50Z
dc.date.available 2017-10-10T04:56:50Z
dc.date.issued 8/3/2017
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2360
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The aim of this study is to determine the photolytic degradation of Carvedilol tartrate. The objective of the study is to determine the photolytic degradation of Cavelon® (Carvedilol) which contained in a blister packing with coating to evaluate the coating is efficient or not.. In this research, photosensitivity of carvedilol is determined in various lighting conditions (control, sunlight, normal light, 25W bulb, and 40W bulb condition). For this study UV photo spectroscope was used. Besides this, physical tests were performed for evaluation of color change, weight variation, thickness and hardness of Cavelon® tablets from same batch according to the specification of USP. A very insignificant fluctuation in result was observed, with average weight 0.0843g, standard deviation ±0.0004, ±0.05 & ±0.012 for weight variation, hardness & thickness test respectively. But in various lighting condition like 25watt bulb, 40watt bulb, and normal room light the potency of carvedilol tartrate were not decreased. But under the direct sunlight the concentration of carvedilol tartrate was decreased percent deviation 1.55%. So it can be said that the Cavelon® containing carvedilol is light sensitive and coating alone is not sufficient to protect the drug from all lights. So that package should be opaque thus no light can pass through the package. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;00604 PHA
dc.subject Carvedilol Tartrate, Photolytic Degradations, UV-spectroscopy, Weight variation, Hardness, Thickness, Potency, USP. en_US
dc.title Photo Degradation Study of Cavelon® (Carvedilol) Using UV-Spectroscopy en_US
dc.type Thesis en_US


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