Abstract:
This work was aimed for the determination of photolytic degradation of carvedilol tartrate. The objective of this study was to determine the effect on carvedilol in various lighting conditions (control, sunlight, normal room light, 25watt & 40watt bulb). Besides, physical tests were performed for evaluation of color change, weight variation of Carvista® tablets from same batch according to the specification of USP. A very insignificant fluctuation in result was observed in weight variation test. Various lighting condition like normal room light, 25watt bulb, 40watt bulb, and direct sunlight the concentration of carvedilol were decreased gradually with percent deviation 2.05%, 5.00%, 12.08% and 20.00% respectively. So it can be said that the Carvista® containing carvedilol is light sensitive and coating alone is not sufficient to protect the drug from light. So that package should be opaque thus light cannot pass through the package.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
