Comparative Dissolution Study of Four Different Brands of Clonazepam Tablets (Cloron, Denixil,Pase, Epnil) With Xetril

Abstract

Clonazepamis an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Clonazepam works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepan.The aim of the present study was to evaluate the dissolution pattern of locally branded drug products of Clonazepam tablets available in Bangladesh. Here I compare the dissolution pattern of four locally marketed drugs With Xetril belongs from BeximcoPharmaceuticals Ltd. Four brands namely: Cloron, Denixil, Epnil, Pase have been under this study. Branded drugs are expensive than locally marketed drug. Substitution of drugs is very essential for the people of under developing country. These five different brands of clonazepam tablets which are available in Bangladesh were collected from a reputed pharmacy store. Three tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 50 minutes for all the brands.In all the cases, standard curve along with the percent release data with time was calculated.