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Photolytic Degradation of Carvista® (Carvedilol): An UV Analysis

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dc.contributor.author Ullah, Md. Wazi
dc.date.accessioned 2017-10-22T06:23:01Z
dc.date.available 2017-10-22T06:23:01Z
dc.date.issued 7/5/2017
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2387
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract This work was aimed for the determination of photolytic degradation of carvedilol tartrate. The objective of this study was to determine the effect on carvedilol in various lighting conditions (control, sunlight, normal room light, 25watt & 40watt bulb). Besides, physical tests were performed for evaluation of color change, weight variation, thickness and hardness of Carvista® tablets from same batch according to the specification of USP. A very insignificant fluctuation in result was observed, with standard deviation ±0.0004, ±0.05 & ±0.012 for weight variation, hardness & thickness test respectively. But in various lighting condition like 25watt bulb, 40watt bulb, direct sunlight and normal room light the concentration of carvedilol tartrate were decreased gradually with percent deviation 11.19%, 12.04%, 8.26% and 19.81% respectively. So it can be said that the Carvista® containing carvedilol is light sensitive and coating alone is not sufficient to protect the drug from light. So that package should be opaque thus light cannot pass through the package. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;00631 PHA
dc.subject Presonil®, Carvedilol Tartrate, Photolytic Degradations, Batch, Weight variation, Hardness, Thickness, Potency, USP. en_US
dc.title Photolytic Degradation of Carvista® (Carvedilol): An UV Analysis en_US
dc.type Thesis en_US


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