EWU Institutional Repository

Antioxidant and Anti-microbial Activity Assessment of Methanol Extract of Garcinia cowa Leaves

Show simple item record

dc.contributor.author Tanha, Farhena Afrose
dc.date.accessioned 2017-10-24T04:20:35Z
dc.date.available 2017-10-24T04:20:35Z
dc.date.issued 7/14/2017
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2394
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract Bangladeshi local plant Garcinia cowa (cow tree) is an abundant source of bioactive phytochemicals. Phytochemical investigations of the plant parts indicated that the leaves best source of secondary metabolites, providing flavonoids, phloroglucinols and xanthones respectively. Seventy eight of these compounds have been identified from the plant and several have seen to posess different pharmacological activities. Garcinia cowa was screened for their anti-microbial and anti-oxidant activities . The part which was being evaluated for its activity was methanol extract of leaves. Methanol extracts of Garcinia cowa leaves exhibited strong anti-oxidant and antibacterial activities . First phyto-chemical test was carried out where methanol extract of leaves showed high content of flavonoid & tannins. DPPH scavenging activity test & total phenolic content test is rendered to monitor the inhibitory activity against oxidation. In DPPH scavenging activity test the IC50 or inhibitory concentration of the sample was obtained ( 28.30 μg/ml ) much more higher than the standard ( Ascorbic acid; IC50 was 1.8194 ) compound. This shows that the methanol extract of leaves have strong anti-oxidant property. Methanol extract of leaves also showed high total phenoilic content ( 223.1333 mg/g ) which indicates that leaf extract of this particular solvent (MeoH) has strong anti-oxidant property .Anti-microbial activity test was also carried out using methanol extract of leaves which showed different sized zone of inhibition for different strains of bacteria . The sensitive bacteria to this extract were Bacillus sereus, Bacillus megaterium , Salmonella typhi , Shigella dysenteriae .Pseudomonas aureaus where highest millimeters of zone of inhibition was formed. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;00638 PHA
dc.subject Antioxidant activity, Anti-microbial activity,Phyto-chemical test,DPPH scavenging activity,Total phenolic content test, Anti-microbial test ,IC50, Zone of inhibition. en_US
dc.title Antioxidant and Anti-microbial Activity Assessment of Methanol Extract of Garcinia cowa Leaves en_US
dc.type Thesis en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account