Determination of the Release Kinetics of Drug from Five Brands of Clonazepam Available in Bangladesh (Clonium, Disopan, Epitra, Rivotril, Epiclone)

Abstract

The purpose of this study was to determine the in vitro release kinetics of five brands of clonazepam tablets available in the local pharmaceutical market of Bangladesh. For this study, five widely prescribed brands Epitra, Epiclone, Rivotril, Clonium and Disopan were chosen. All of these brands were of 0.5 mg Clonazepam with strip packaging. The dissolution was carried out using USP apparatus-II and the analysis was performed with the UV spectroscopy. To find out the release kinetics K0 (for zero order), K1 (for first order), Kh (for Higuchi model) were determined. The R2 value for each kinetics was also determined which indicated the linearity of release kinetics for each brand. The study found no brand to follow the zero-order and first order kinetics mostly except Higuchi’s drug release profile. The brands showing different R2 values for Higuchi Drug release profile are Clonium (R2=0.9843), Disopan (R2=0.9548), Epiclone (R2=0.9726), Epitra (R2=0.9578), Rivotril (R2=0.9334) was the highest amongst the R2 values comparing to zero order and first order values. So, this study assumes that the available Clonazepam tablet brands available in Bangladesh generally follow the Higuchi’s drug release kinetics.