Abstract:
Recently worldwide different researches on medicinal plants are holding attention. A
number of experiments were found where medicinal plants have been used for different
complementary and traditional systems to promote newer and safer drugs. Keep this in mind
our current study was designed to find out CNS depressant activity from methanol extracts
of leaves of Stereospermumchelonoides. In our present study, we have checked above
mentioned pharmacological activities of our experimental plant extracts in mice. By the
open-field and hole-board method, CNS depressant activity was inspected with the decline
of locomotor activity on mice. Here crude extracts were administered to mice at a dose of
250mg/kg and 500mg/kg. All the results of our experiments were statistically significant
(p<0.05, p<0.01, p<0.001). In CNS depressant activity tests, the movement of mice
decreased in a dose depending manner comparing to the standard diazepam. In conclusion
we can say that our present findings suggest that methanol extracts of
Stereospermumchelonoides leaves contain potent CNS depressant principles. It can also be
said that the obtained results provide a support for the use of this plant in traditional
medicine and its further investigation.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
