Abstract:
Among the pathologic hypotheses of Alzheimer’s disease (AD), cholinergic deficit and
oxidative stress have been implicated as two major hallmarks. Therefore, inhibition of
cholinesterase and oxidation are the two promising strategies in the development of a drug for
AD. Mimusa pudica plant extract is used in this research to investigate its anticholinesterase
and antioxidant potentials. Anticholinesterase activity was measured by modified Ellman’s
method. Antioxidant potentials were evaluated by the assay of reducing power, radical
scavenging. The Methanolic extract showed strong antioxidant effect. Additionally, the
extract exhibited pronounced reducing capacity. The plant extract found moderate inhibitor of
cholinesterase (Both Acetylcholinesterase and Butyrylcholinesterase). The tested sample
reflects potential antioxidative and moderate anticholin-esterase inhibitory effect which may
warrant its effectiveness in the treatment of AD.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.
