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Evaluation of Diclofenac 12H SR Tablet From Methocel 100LVCR

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dc.contributor.author Biswas, Tanjir Ahmed
dc.date.accessioned 2018-01-31T09:28:10Z
dc.date.available 2018-01-31T09:28:10Z
dc.date.issued 12/13/2009
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2444
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract In the present study an effort has been made to formulate 6 dilcofenac sR with Methocel K- 15MCR and Methocel lOOLVCR polymer to sustain the release of Diclofenac r2H from Diclofenac sustained release tablet Different ratio of Methocel K- 15MCR and Methocel r ooLVCR as I :5, 3:4,2:5,4:3,3:3,3:5 of total weight of tablet matrix, were used to prepare sustained release tablet matrix by direct compression The dissolution study of the tablet matrices of different formulations were carried out in the gastric medium (pH r.3) for first two hours and then in the intestinal medium (pH 6.g) for 10 hours using usp dissolution apparatus. From the release pattern we observed that 2:5 and 3:5 of Methocel K_l5MCR and Methocel lOOLVCR showed the desired sustained release by direct compression method. The drug release patterns were simulated in different kinetic orders such as Zero order, First order and Higuchi release kinetics to assess the release mechanism. From the study we observed that first order was the predominant release mechanism than higuchi and. zero order kinetics- The physicar criterion of formula(F-3 and F-6) were evaluated bulk density, compressibility index, total porosity, angle of repose, drug contain for granules hardness, friability, thickness, weight variation test, drug content of finished product. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;00020 PHA
dc.subject Diclofenac 12H SR Tablet From Methocel 100LVCR en_US
dc.title Evaluation of Diclofenac 12H SR Tablet From Methocel 100LVCR en_US
dc.type Thesis en_US


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