Determination of CNS Activity of Methanol Extract Of Stereospermum Chelonoides’s Bark.

Abstract

Recently worldwide different researches on medicinal plants have grabbed attention. A number of experiments were found where medicinal plants have been used for different complementary and traditional systems to promote newer and safer drugs. Keep this in mind the current study was designed to find out CNS depressant and analgesic principles from chloroform solvent extracts of stereospermum chelonoides. The traditional use of this plant is in the treatment of dysentery, leucorrhoea, dysmenorrhoea, haemoptysis and catarrhal bronchitis. It is also claimed that the plant is a good reservoir of such compounds which have the possibility to be a better source of CNS depressant agents in living organism. In this study, above mentioned pharmacological activities of the experimental plant extract was checked in swiss albino mice. By the open field and hole cross method, CNS depressant activity was inspected with the decline of locomotor activity on mice.. Here methanol extract of s.chelonoides were administered to mice at a dose of 250 mg/kg and 500 mg/kg. All the results of the experiments were statistically significant (p<0.001). In CNS depressant activity tests, the movement of mice decreased in a dose depending manner comparing to the standard diazepam. The experimental extracts have good cns effect comparing to control group.. In conclusion it can be said that methanol extract of s.chelonoidespossesses good CNS depressant as well as analgesic activity.