Abstract:
Purpose: The research work was carried out to determine the pharmacological activities
of methanolic extract of Phyla Nodiflora.
Method: Methanolic extract was administered orally to the animal model (Swiss albino)
and the effects were determined by comparing with respect to control group which
were treated with 5% CMC. For every experiment positive control was used. Different
experiments were used to determine the pharmacological profile which was
Collected from internationally published publications and journals.
Result: The Laxative Effect was evaluated by Charcoal meal GI transit test where
methanolic extract at dose of 800 mg/kg body weight increase the charcoal transit
which compare with positive control.
The CNS activity was evaluated by open field method and hole board test. In the open
field method and hole board experiment the crude extract of Phyla Nodiflora.
(200mg/kg,400mg/kg & 800mg/kg) dose dependently reduces the number of peripheral
locomotion, central locomotion and leaning in the open field test and reduces the number
of head dipping and head poking in the hole board test. The reduction is significant
(***p<0.001) when it is compared to the standard drug.
The aim of the study was also to investigate the possible toxicity of the plant Phyla
Nodiflora and especially to establish the safety of the methanolic extract of this plant by
focusing on its acute and chronic toxicity in mice.
Conclusion: After summarize all the results it can say that Phyla Nodiflora may have
several pharmacological activities but to prove the hypothesis it need further
higher studies.
Keywords:
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh.
