In Vitro Release Pattern of Indapamide From Repres SR Matrix Tablet

Abstract

Repres SR matrix tablets were collected from the market and those were characterized by physical parameters like hardness, thickness, weight variations and dissolution studies. Indapamide release was explored using the method adorned in Appendix XII B: Dissolution tests for tablets and capsules of British Pharmacopoeia. Hardness study of the withdrawn samples from the market was carried out by hardness tester (Veego, Germany). Thickness study of the samples was measured by slide calipers. Dissolution study of the taken samples was explored by using dissolution tester (RC6, Vanguard Pharmaceuticals, and USA) to assess release kinetics. Consequences of the physical tests are follows; Mean hardness value of Indapamide matrix tablets was found to be l0.5kg. Mean thickness value of Indapamide matrix tablets were found to be 0.69cm. Mean weight variation value of Indapamide matrix tablets were found to be 0.956. Beside this the release pattern of the samples was determined through dissolution test. And further discussion drawn on itwhich has been included atthe following section of this paper. To conclude, the results obtained against different physical test for Repres SR matrix tablets were justified with the specification (British Pharmacopeias) whether they met the specified standard.