Abstract:
Sensit tablet is a combination product of flupentixol and melitracen in which Flupentixol is neuroleptic and melitracen is anti-depressant drug. This formulation is widely used in
Bangladesh in severe depression and neuralgia which have high prevalence in Bangladesh perspective. The purpose of this work is to find whether the drugs photosensitive or not. The stability of drugs in the formulation was determined by scrutinizing the potency level by spectrphotometric method and physical parameters of the tablet. Specific amounts of tablet were exposed to different environment including sunlight, florescent light and normal room condition at definite temperature. The sample then was collected at definite time interval and physical parameter and potency was later determined. All the cases, the physical parameters were within range but for potency degraded as downhill. Throughout the process this was ensured adequate drug solubility and maximum assay sensitivity. The linearity ranges for the two drugs were measured accurately with precision. From the study of the project it is concluded that the drugs Require light protection to remain stable within the shelf life.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh.
