EWU Institutional Repository

Cytotoxic & Anti-oxidant Activity of Ethyl Acetate (EA) Fraction of F. hispida Leaf Extract

Show simple item record

dc.contributor.author Mitu, Jannatul Ferdous
dc.date.accessioned 2018-03-08T07:34:52Z
dc.date.available 2018-03-08T07:34:52Z
dc.date.issued 12/31/2017
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2612
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The study was designed for pharmacological investigation of ethyl acetate (EA) fraction of methanol extract of the leaves of Ficus hispida (Family: Moraceae). The powdered leaves of Ficus hispida were extracted with methanol and then partitioned with n-hexane, dichloromethane and ethyl acetate consecutively. The EA fraction remaining was investigated for total flavonoid content, total phenol content, brine shrimp lethality test. The fraction contained 139.167mg AAE/gm of dried extract in total phenolic content assay and 9.73mg quercetin/gm of dried extract in total flavaniod content assay. Screening for cytotoxic properties using brine shrimp lethality bioassay with tamoxifen (LC50 value of 35.23 μg/ml) as positive control showed that the fraction have considerable cytotoxic potency exhibiting LC50 value of 1.79 μg/ml. The EA fraction showed strong cytotoxic activity, low antioxidant activity and low to moderate antimicrobial activity. Further investigations are needed for the proper identification and isolation of these bioactive compounds to produce safer drugs for treatment of harmful diseases. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00667
dc.subject Ficus hispida, Brine shrimp lethality bio-assay, phenolic content, flavonoid content. en_US
dc.title Cytotoxic & Anti-oxidant Activity of Ethyl Acetate (EA) Fraction of F. hispida Leaf Extract en_US
dc.type Thesis en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account