A Pharmacological Investigation on CNS Activity of Chloroform Extract of Syzygium samarangense Leaves

Abstract

Current study was designed to find out CNS activity from Chloroform extract of leaves of Syzygium samarangense. The study was conducted in-vivo using Swiss albino mice model. With the help of open-field and hole-board method, CNS activity was inspected with the decline of locomotor activity on mice. Crude extract was administered to mice at a dose of 100mg/kg and 200mg/kg body weight. All the results of our experiments were statistically significant (p<0.05, p<0.01, p<0.001). In CNS activity tests, the movement of mice decreased in a dose-depending manner comparing to the standard, Diazepam. In conclusion, we can say that our present findings suggest that Chloroform extracts of Syzygium samarangense leaves contain potent CNS Depressant principles. It can also be said that the obtained results provide a support for the use of this plant in traditional medicine and its further investigation.